In vitro and in silico studies of a Zn(II) complex as a potential therapeutic agent for breast cancer.

ABSTRACT: Breast cancer (BC) is one of the most life-threatening diseases of women's health worldwide. This work was conducted to assess the anti-BC potency of a new Zn(II)-based complex. The Zn(II) complex coordinated to dimethoxy-substituted bipyridine was synthesized and its molecular structure was elucidated as [Zn(^2Meobpy)₃](clo₄)₂ (^2Meobpy-Zn) by single-crystal X-ray diffraction, ^2Meobpy represents 4,4'-dimethoxy-2,2'-bipyridine. The cytotoxicity results indicated that ^2Meobpy-Zn, unlike cisplatin, acts potently and selectively on the human breast cancer cells (MCF-7) compared to normal murine embryo cells (NIH/3T3) by IC₅₀ value of 4.6 ± 0.5 µm and selectivity index (SI) of 2.0 over 48 h. ^2Meobp

SUBMITTER: Anjomshoa M 

PROVIDER: S-EPMC11589879 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature