Three-dimensional anisotropic hyperelastic constitutive model describing the mechanical response of human and mouse cervix.

ABSTRACT: The mechanical function of the uterine cervix is critical for a healthy pregnancy. During pregnancy, the cervix undergoes significant softening to allow for a successful delivery. Abnormal cervical remodeling is suspected to contribute to preterm birth. Material constitutive models describing known biological shifts in pregnancy are essential to predict the mechanical integrity of the cervix. In this work, the material response of human cervical tissue under spherical indentation and uniaxial tensile tests loaded along different anatomical directions is experimentally measured. A deep-learning segmentation tool is applied to capture the tissue deformation during the uniaxial tensile tests. A 3-dimensional, equilibrium anisotropic continuous fiber constitutive model is formulated, consideri

SUBMITTER: Shi L 

PROVIDER: S-EPMC11590015 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature