Distinct substrate specificities of the three catalytic subunits of the Trichomonas vaginalis proteasome.

ABSTRACT: The protozoan parasite Trichomonas vaginalis (Tv) causes trichomoniasis, the most common non-viral sexually transmitted infection in the world. Although Tv has been linked to significant health complications, only two closely related 5-nitroimidazole drugs are approved for its treatment. The emergence of resistance to these drugs and lack of alternative treatment options poses an increasing threat to public health, making development of novel anti-Trichomonas compounds an urgent need. The proteasome, a critical enzyme complex found in all eukaryotes has three catalytic subunits, β1, β2, and β5 and has been validated as a drug target to treat trichomoniasis. With the goal of developing tools to study the Tv proteasome, we isolated the enzyme complex and identified inhibitors that preferenti

SUBMITTER: Fajtova P 

PROVIDER: S-EPMC11590128 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature