Exosomes secreted from human-derived adipose stem cells prevent progression of osteonecrosis of the femoral head.

ABSTRACT:

Background

Osteonecrosis of the femoral head (ONFH) primarily affects young individuals and is a leading cause of total hip arthroplasty in this population. Joint-preserving regenerative therapies involving core decompression (CD), enhanced with cells, growth factors, and bone substitutes, have been developed but lack extensive validation. Exosomes are emerging as a promising regenerative therapy. Human adipose stem cell (hADSC)-derived exosomes exhibit angiogenic and wound-healing effects on damaged and diseased tissues, suggesting their potential efficacy in treating early-stage ONFH. We aimed to investigate the efficacy of hADSC-derived exosomes based on CD in a medium-sized animal model (rabbit).

Methods

Exosomes were extracted using the ultrafiltration filter technique

SUBMITTER: Ikezaki T 

PROVIDER: S-EPMC11590306 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature