A novel human protein-coding locus identified using a targeted RNA enrichment technique.

ABSTRACT:

Background

Accurate and comprehensive genomic annotation, including the full list of protein-coding genes, is vital for understanding the molecular mechanisms of human biology. We have previously shown that the genome contains a multitude of yet hidden functional exons and transcripts, some of which might represent novel mRNAs. These results resonate with those from other groups and strongly argue that two decades after the completion of the first draft of the human genome sequence, the current annotation of human genes and transcripts remains far from being complete.

Results

Using a targeted RNA enrichment technique, we showed that one of the novel functional exons previously discovered by us and currently annotated as part of a long non-coding RNA, is actually a part of a

SUBMITTER: Tang L 

PROVIDER: S-EPMC11590353 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature