A systematic review of candidate genes and their relevant pathways for metastasis among adults diagnosed with breast cancer.

ABSTRACT:

Background

Presently incurable, metastatic breast cancer is estimated to occur in as many as 30% of those diagnosed with early-stage breast cancer. Timely and accurate identification of those at risk for developing metastasis using validated biomarkers has the potential to have profound impact on overall survival rates. Our primary goal was to conduct a systematic review and synthesize the existing body of scientific knowledge on the candidate genes and their respective single nucleotide polymorphisms associated with metastasis-related outcomes among patients diagnosed with breast cancer. This knowledge is critical to inform future hypothesis-driven and validation research aimed at enhancing clinical decision-making for breast cancer patients.

Methods

Using PRISMA guidelines

SUBMITTER: Gehling GM 

PROVIDER: S-EPMC11590482 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature