Behavioural and neuropsychological outcomes in children exposed in utero to maternal labour epidural analgesia.

ABSTRACT:

Background

Recent studies report conflicting results regarding the relationship between labour epidural analgesia (LEA) in mothers and neurodevelopmental disorders in their offspring. We evaluated behavioural and neuropsychological test scores in children of mothers who used LEA.

Methods

Children enrolled in the Raine Study from Western Australia and delivered vaginally from a singleton pregnancy between 1989 and 1992 were evaluated. Children exposed to LEA were compared with unexposed children. The primary outcome was the parent-reported Child Behaviour Checklist (CBCL) reporting total, internalising, and externalising behavioural problem scores at age 10 yr. Score differences, an increased risk of clinical deficit, and a dose-response based on the duration of LEA exposure

SUBMITTER: Isik OG 

PROVIDER: S-EPMC11590713 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature