A prospective cohort study examining the association between the periconceptual vaginal microbiota and first-trimester miscarriage in Kenyan women.

ABSTRACT:

Background

Studies evaluating the association between the vaginal microbiota and miscarriage have produced variable results.

Objective

This study evaluated the association between periconceptual and first-trimester vaginal microbiota and women's risk for miscarriage.

Methods

At monthly preconception visits and at 9-12 weeks gestation, women collected vaginal swabs for molecular characterisation of the vaginal microbiota. Participants who became pregnant were followed to identify miscarriage versus pregnancy continuing to at least 20 weeks gestation.

Results

Forty-five women experienced miscarriage and 144 had pregnancies continuing to ≥20 weeks. A principal component analysis of periconceptual and first-trimester vaginal bacteria identified by 16S rRNA gene PCR

SUBMITTER: McClelland RS 

PROVIDER: S-EPMC11590749 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature