Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma.

ABSTRACT:

Background

Despite the successful application of immunotherapy, both innate and acquired resistance are typical in melanoma. Ferroptosis induction appears to be a potential strategy to enhance the effectiveness of immunotherapy. However, the relationship between the status of ferroptosis and the effectiveness of immunotherapy, as well as viable strategies to augment ferroptosis, remains unclear.

Methods

A screening of 200 cardiovascular drugs obtained from the Food and Drug Administration-approved drug library was conducted to identify the potential ferroptosis sensitizer. In vitro and in vivo experiments explored the effects of propafenone on ferroptosis in melanoma. Animal models and transcriptomic analyses evaluated the therapeutic effects and survival benefits of propafe

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC11590812 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature