Assessment of bleeding events in patients receiving DOACs with or without statins to treat venous thromboembolism: insights from the RIETE registry.

ABSTRACT:

Objective

To evaluate the impact of coadministering statins with direct oral anticoagulants (DOACs) on the risk of major bleeding events in patients with venous thromboembolism (VTE).

Design

Observational cohort analysis based on a multicentre international registry.

Setting

Data were extracted from the Registro Informatizado de Enfermedad TromboEmbolica Registry, which involves 205 centres across 27 countries.

Participants

A total of 73 659 patients diagnosed with VTE were classified based on their anticoagulant therapy (DOACs) versus low-molecular-weight heparin (LMWH) or vitamin K antagonists (VKAs) and concurrent use of statins.

Methods

Multivariable Cox proportional hazards models adjusted for confounding variables to assess the risk of major bleedi

SUBMITTER: Del Giorno R 

PROVIDER: S-EPMC11590820 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature