Altered structural and functional homotopic connectivity associated with cognitive changes in SLE.

ABSTRACT:

Objective

Previous studies have revealed functional changes within the cerebral hemispheres of patients with SLE; however the changes between cerebral hemispheres are still unknown. The present study aimed to explore the functional and structural changes between bilateral hemispheres using functional MRI and find their relationship with cognition in patients with SLE.

Methods

54 patients with SLE and 32 age-matched and sex-matched healthy controls (HCs) underwent MRI scanning and neuropsychological testing, and clinical data was collected in patients with SLE. Voxel-mirrored homotopic connectivity (VMHC) values and grey matter volume were calculated for all subjects. Correlation analysis was established to determine the relationship between VMHC values, grey matter volume an

SUBMITTER: Ni S 

PROVIDER: S-EPMC11590855 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature