<i>Armillaria mellea</i> Mycelia Alleviate PM2.5-Induced Pulmonary Inflammation in Murine Models.

ABSTRACT: Particulate matter (PM) with an aerodynamic diameter of ≤2.5 μm (PM2.5) significantly contributes to various disease-related respiratory inflammations. Armillaria mellea, recognized for its medicinal properties, could alleviate these respiratory ailments. However, its efficacy against PM2.5-induced inflammation remains elusive. In this study, we investigated whether A. mellea mycelia could mitigate PM2.5-induced respiratory inflammation and assessed the underlying mechanisms. Our results showed that A. mellea mycelia significantly reduced PM2.5-induced nitric oxide (NO) production and nuclear factor (NF)-κB activation in macrophages. Furthermore, A. mellea mycelia suppressed the expression of inflammatory mediators, indicating their potent antioxidant and anti-i

SUBMITTER: Huang YP 

PROVIDER: S-EPMC11590969 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature