Data-Driven Insights into the Association Between Oxidative Stress and Calcium-Regulating Proteins in Cardiovascular Disease.

ABSTRACT: A growing body of biomedical literature suggests a bidirectional regulatory relationship between cardiac calcium (Ca²⁺)-regulating proteins and reactive oxygen species (ROS) that is integral to the pathogenesis of various cardiac disorders via oxidative stress (OS) signaling. To address the challenge of finding hidden connections within the growing volume of biomedical research, we developed a data science pipeline for efficient data extraction, transformation, and loading. Employing the CaseOLAP (Context-Aware Semantic Analytic Processing) algorithm, our pipeline quantifies interactions between 128 human cardiomyocyte Ca²⁺-regulating proteins and eight cardiovascular disease (CVD) categories. Our machine-learning analysis of CaseOLAP scores reveals that the molecular

SUBMITTER: Panday N 

PROVIDER: S-EPMC11590986 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature