From Burst to Sustained Release: The Effect of Antibiotic Structure Incorporated into Chitosan-Based Films.

ABSTRACT: Background/Objectives: Medical devices are susceptible to bacterial colonization and biofilm formation, which can result in severe infections, leading to prolonged hospital stays and increased burden on society. Antibacterial films have the potential to assist in preventing biofilm formation, thereby reducing administration of antibiotics and the emergence of antibiotic-resistant strains. In a previous study, a chitosan-based matrix crosslinked with tannic acid and loaded with gentamicin was reported. In this study, five different antibiotics (moxifloxacin, ciprofloxacin, trimethoprim, sulfamethoxazole or linezolid) were loaded into these chitosan-based films, and their impact on the release behavior carefully assessed. Methods: The samples were characterized according to the

SUBMITTER: Sczesny NF 

PROVIDER: S-EPMC11591004 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature