Potent Antimicrobial Azoles: Synthesis, In Vitro and In Silico Study.

ABSTRACT: Background/Objectives: The increase in fungal infections, both systemic and invasive, is a major source of morbidity and mortality, particularly among immunocompromised people such as cancer patients and organ transplant recipients. Because of their strong therapeutic activity and excellent safety profiles, azole antifungals are currently the most extensively used systemic antifungal drugs. Antibacterial properties of various topical antifungals, such as oxiconazole, which features oxime ether functionality, were discovered, indicating an exciting prospect in antimicrobial chemotherapy. Methods: In this study, eleven new oxime ether derivatives with the azole scaffold (5a-k) were synthesized and tested for their antimicrobial effects using the microdilution meth

SUBMITTER: Ozdemir Z 

PROVIDER: S-EPMC11591103 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature