Heat Stress Impairs Endometrial Function During Implantation by Regulating Autophagy in Hainan Black Goat.

ABSTRACT: Heat stress (HS) is a significant factor that adversely affects the health, welfare, and productivity of domestic animals, particularly impacting embryo implantation rates. However, the effects of HS on endometrial function during the peri-implantation period in Hainan black goats remain unclear. This study explores the influence of HS on the endometrium of these goats. We collected uterine tissue samples from both control and heat-stressed goats and performed in vitro experiments using a 2 × 2 factorial design. This design included two temperature conditions (37 °C as the control and 42 °C to simulate heat stress) and two pharmacological treatments: chloroquine (CQ), an autophagy inhibitor, and rapamycin (RAPA), an autophagy activator. Our results showed that heat stress initially suppres

SUBMITTER: Li X 

PROVIDER: S-EPMC11591286 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature