Ciprofloxacin Concentrations in Food Could Select for Quinolone Resistance in <i>Klebsiella pneumoniae</i>: An In Vivo Study in <i>Galleria mellonella</i>.

ABSTRACT: Background: The use of antimicrobials to treat food animals leaves antimicrobial residues in foodstuffs. The World Health Organization (WHO) defines the acceptable daily intakes (ADIs) of these residues as the dose of these antimicrobials that is safe for an average human to consume on a daily basis. We hypothesized that the lowest dose of ciprofloxacin classified as safe by the WHO could select for ciprofloxacin-resistant strains of Klebsiella pneumoniae in a Galleria mellonella model. Objectives: We aimed to evaluate if the consumption of peri-ADI doses of ciprofloxacin could select for ciprofloxacin-resistant (Ser464Phe, GyrB, ciprofloxacin MIC of 4 µg/mL) compared to -susceptible (isogenic, ciprofloxacin MIC of 0.047 µg/mL) strains of K. pneumoniae in

SUBMITTER: Panis N 

PROVIDER: S-EPMC11591287 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature