Anti-<i>Staphylococcus aureus</i> Activity of Volatile Phytochemicals and Their Combinations with Conventional Antibiotics Against Methicillin-Susceptible <i>S. aureus</i> (MSSA) and Methicillin-Resistant <i>S. aureus</i> (MRSA) Strains.

ABSTRACT:

Background

MSSA and MRSA strains are challenging human pathogens that can develop resistance to antibiotics, highlighting the need for alternative antimicrobial agents. Plant metabolites, particularly volatile phytochemicals, may offer promising antimicrobial properties. The aim was to evaluate the antimicrobial and antibiofilm efficacy of various commercial volatile phytochemicals from the terpene and terpenoid groups against reference MSSA and MRSA strains, focusing on synergistic effects in both binary combinations and combinations with antibiotics.

Methods

The microdilution method was used to determine the minimum inhibitory concentrations (MICs) for antibiotics and phytochemicals. The checkerboard method assessed synergistic interactions between phytochemicals and betwe

SUBMITTER: Nikolic I 

PROVIDER: S-EPMC11591321 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature