Antibiotic-Induced Immunosuppression-A Focus on Cellular Immunity.

ABSTRACT: Antibiotics are the fundamental treatment for bacterial infections. However, they are associated with numerous side effects. Their adverse effects on the immune system are increasingly recognised, with several mechanisms identified. In this review, we focus on their direct effects on cellular immunity. We review the effects of antibiotics on mitochondrial function and how they impair specific immune cell functions including chemotaxis, phagocytosis, cytokine production, antigen presentation, and lymphocyte proliferation. Findings are described in a multitude of in vivo and in vitro models. However, their impact on patient immunity and clinical outcomes requires further research. Awareness of the potential adverse effects of antibiotics may improve antimicrobial stewardship. T

SUBMITTER: Snow TAC 

PROVIDER: S-EPMC11591424 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature