Estrogen Regulates Ca²⁺ to Promote Mitochondrial Function Through G-Protein-Coupled Estrogen Receptors During Oocyte Maturation.

ABSTRACT: Estrogen is a steroid hormone that plays a key role in regulating many physiological processes, such as follicle activation and development and oocyte maturation in mammals. Ca²⁺ is crucial in oogenesis, oocyte maturation, ovulation, and fertilization. However, the mechanism by which estrogen regulates Ca²⁺ during oocyte maturation in mice has not been reported. This study revealed that Ca²⁺ levels in oocytes significantly increase during the 4-12 h period in vitro. Oocytes treated with 0.1 µM estrogen and 1 µM G1, a G-protein-coupled estrogen receptor (GPER) agonist, showed significantly increased Ca²⁺ levels, while treatment with 1 µM G15, an antagonist of GPER, significantly decreased Ca²⁺ levels. Notably, estrogen regulates Ca

SUBMITTER: Liu Q 

PROVIDER: S-EPMC11591592 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature