Ischemic Postconditioning Regulates New Cell Death Mechanisms in Stroke: Disulfidptosis.

ABSTRACT:

Background and objective

Stroke poses a critical health issue without effective neuroprotection. We explore ischemic postconditioning's (IPostC) potential to mitigate stroke-induced brain injury, focusing on its interaction with disulfidptosis, a novel cell death pathway marked by protein disulfide accumulation. We aim to clarify IPostC's protective mechanisms against stroke through gene sequencing and experimental analysis in mice.

Methods

Through our initial investigation, we identified 27 disulfidptosis-related genes (DRGs) and uncovered their interactions. Additionally, differential gene analysis revealed 11 potential candidate genes that are linked to disulfidptosis, stroke, and IPostC. Our comprehensive study employed various analytical approaches, including machine le

SUBMITTER: Liu S 

PROVIDER: S-EPMC11591815 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature