Inhibition of Glycolysis Alleviates Chronic Unpredictable Mild Stress Induced Neuroinflammation and Depression-like Behavior.

ABSTRACT:

Background

Growing evidence suggests that glucose metabolism plays a crucial role in activated immune cells, significantly contributing to the occurrence and development of neuroinflammation and depression-like behaviors. Chronic stress has been reported to induce microglia activation and disturbances in glucose metabolism in the hippocampus.

Aims

This study aims to investigate how chronic stress-mediated glycolysis promotes neuroinflammation and to assess the therapeutic potential of the glycolysis inhibitor, 2-deoxy-D-glucose (2-DG), in a model of chronic stress-induced neuroinflammation and depression-like behavior.

Methods

In in vitro studies, we first explored the effects of 2-DG on the inflammatory response of microglia cells. The results showed that corticoster

SUBMITTER: Liu B 

PROVIDER: S-EPMC11591872 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature