Immune Suppression and Rapid Invasion of Nile Tilapia Gills Following an Acute Challenge by Flavobacterium davisii.

ABSTRACT: Flavobacterium davisii is one of the causative agents of columnaris disease, significantly impacting Nile tilapia aquaculture. This study examines the invasion and immune evasion mechanisms of a highly virulent F. davisii strain through transcriptomic profiling of tilapia gills following acute immersion. We identified 8192 differentially expressed genes (DEGs) at 2 h, 6 h, and 12 h post-infection. They are enriched in pathways related to oxidative stress, immune suppression, tissue necrosis, and bacterial infection. Notably, early overexpression of rhamnose-binding lectin and mucin genes facilitated bacterial adhesion. Key immune genes, including those encoding major histocompatibility complex (MHC), immunoglobulins (Ig), Toll-like receptors (TLRs), and chemokines, were downr

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11592246 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature