Deciphering the Role of ASPM in Breast Cancer: A Comprehensive Multicohort Study.

ABSTRACT:

Background

Assembly factor for spindle microtubules (ASPM) has gained significant attention in cancer research due to its association with tumor growth and progression. Through the analysis of large-scale genomic datasets, ASPM has been identified as the top upregulated gene in breast cancer (BC), characterized by high proliferation. This multicohort study aimed to investigate the clinicopathological and prognostic significance of ASPM mRNA and protein expression in BC.

Methods

ASPM mRNA expression was assessed using the Cancer Genome Atlas (TCGA) BC cohort and has been further validated in the Molecular Taxonomy of BC International Consortium (METABRIC) (n = 1980), The Uppsala cohort (n = 249), in addition to the combined multicentric cohort (n = 7252).

SUBMITTER: Ibrahim A 

PROVIDER: S-EPMC11592464 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature