Identification of Molecular Subtypes and Prognostic Traits Based on Chromosomal Instability Phenotype-Related Genes in Lung Adenocarcinoma.

ABSTRACT: Lung adenocarcinoma (LUAD) exhibits significant molecular heterogeneity; however, previous studies have not fully explored its classification into distinct molecular subtypes. Here, we identified LUAD-significant chromosomal instability (CIN) phenotype genes (n = 24) using a TCGA-LUAD cohort (n = 592) and evaluated their ability to predict pathologic grade. Unsupervised clustering and principal component analysis revealed that LUAD patients could be classified into CIN phenotype-related subtypes (Group^Low, Group^Moderate, and Group^High), each exhibiting distinct transcriptomic patterns. Notably, the Group^High showed significantly poor overall survival [OS; hazard ratio (HR) = 1.43, p-value < 10^-3] and disease-free s

SUBMITTER: Jeon Y 

PROVIDER: S-EPMC11592823 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature