AR (CAG)_n Microsatellite and APEX1 c.444T>G (p.Asp148Glu) Polymorphisms as Independent Prognostic Biomarkers in Prostate Cancer: Insights from an Argentinian Cohort.

ABSTRACT:

Background/objectives

Prostate cancer (PCa) is the leading malignancy and the third most common cause of cancer-related death in Argentinian men. Predicting outcomes in localized PCa remains difficult due to tumor heterogeneity. In this study, we assessed the impact of AR (CAG)_n and APEX1 c.444T>G polymorphisms on biochemical relapse in Argentine patients with localized PCa.

Methods

We genotyped blood samples from 123 PCa patients for AR (CAG)_n and APEX1 p.Asp148Glu (c.444T>G) polymorphisms. Associations with clinicopathological parameters and biochemical relapse-free survival (BRFS) were assessed.

Results

AR (CAG)_20-23 was associated with a family history of breast/ovarian cancer (p = 0.0469).

SUBMITTER: Pascual G 

PROVIDER: S-EPMC11592882 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature