Effects of TMEM232 Variant on Infant Atopic Dermatitis According to Maternal Factors.

ABSTRACT: Background: Atopic dermatitis (AD) is caused by interactions between genetic susceptibility and environmental factors. Transmembrane protein 232 (TMEM232) is one of the genes strongly implicated in AD. Methods: In the present study, we aimed to investigate the association between AD with variants within TMEM232 based on maternal factors, including a history of allergic diseases, and sensitization to Der f. We performed a candidate gene association study involving the Cohort for Childhood Origins of Asthma and Allergic Diseases. Results: A single variant of the TMEM232 gene, rs17132261, was found to be significantly associated with AD. Subjects carrying the wild-type allele (C) of rs17132261 had higher total IgE than those carrying the variant rs171

SUBMITTER: Choi EA 

PROVIDER: S-EPMC11593446 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature