ΜicroRNA (miRNA) Variants in Male Infertility: Insights from Whole-Genome Sequencing.

ABSTRACT:

Background/objectives

Male infertility is a complex condition with various underlying genetic factors. microRNAs (miRNAs) play a crucial role in gene regulation, and their disruption can significantly impact fertility. This study aimed to identify variants within miRNA genes and elucidate their impact on male infertility.

Methods

Whole genome sequencing was performed on blood samples from men with asthenozoospermia, oligozoospermia, and teratozoospermia, compared to normozoospermic controls. The analysis revealed a significant number of unique variants in each infertile group. We subsequently focused on variants in miRNA regions, followed by an in silico analysis to investigate the role of the identified variants and miRNAs in male infertility.

Results

Focused analysi

SUBMITTER: Kyrgiafini MA 

PROVIDER: S-EPMC11593656 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature