Gene Expression and Alternative Splicing Analysis in a Large-Scale Multiple Sclerosis Study.

ABSTRACT: Multiple Sclerosis (MS) is an autoimmune neurodegenerative disease affecting approximately 3 million people globally. Despite rigorous research on MS, aspects of its development and progression remain unclear. We utilized a publicly available RNA-seq dataset (GSE138614) consisting of the post-mortem white matter tissues of five donors without any neurological disorders and ten MS patient donors. We investigated gene expression levels correlated with tissue inflammation and alternative splicing to identify possible pathological isoforms in MS tissues. We identified RNA-binding motifs, differentially expressed RNA-binding proteins, and single-nucleotide polymorphisms (SNPs) to unravel possible mechanisms of alternative splicing. Genes with expression changes that were positively correlated w

SUBMITTER: Sak M 

PROVIDER: S-EPMC11593658 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature