Novel Gene Biomarkers Specific to Human Mesenchymal Stem Cells Isolated from Bone Marrow.

ABSTRACT: In this paper, we present a comparative analysis of the transcriptomic profile of three different human cell types: hematopoietic stem cells (HSCs), bone marrow-derived mesenchymal stem cells (MSCs) and fibroblasts (FIBs). The work aims to identify unique genes that are differentially expressed as specific markers of bone marrow-derived MSCs, and to achieve this undertakes a detailed analysis of three independent datasets that include quantification of the global gene expression profiles of three primary cell types: HSCs, MSCs and FIBs. A robust bioinformatics method, called GlobalTest, is used to assess the specific association between one or more genes expressed in a sample and the outcome variable, that is, the 'cell type' provided as a single univariate response. This outcome va

SUBMITTER: Muntion S 

PROVIDER: S-EPMC11593895 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature