Metabolic Transcriptional Activation in Ulcerative Colitis Identified Through scRNA-seq Analysis.

ABSTRACT:

Background

Ulcerative colitis is a chronic inflammatory disease affecting the colon. During chronic inflammation of epithelial cells, lipid metabolism via pro-inflammatory eicosanoids is known to modify the immune response.

Methods

Starting from the Mammalian Metabolic Database, the expression of metabolic enzymes was investigated in two independent cohorts from transcriptome datasets GSE38713 and GSE11223, which analyzed ulcerative colitis tissue samples from the digestive tract.

Results

In the first cohort, 145 differentially expressed enzymes were identified as significantly regulated between ulcerative colitis tissues and normal controls. Overexpressed enzymes were selected to tune an Elastic Net model in the second cohort. Using the best parameters, the model ach

SUBMITTER: Desterke C 

PROVIDER: S-EPMC11593927 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature