CXCR3-CXCL11 Signaling Restricts Angiogenesis and Promotes Pericyte Recruitment.

ABSTRACT:

Background

Endothelial cell (EC)-pericyte interactions are known to remodel in response to hemodynamic forces; yet there is a lack of mechanistic understanding of the signaling pathways that underlie these events. Here, we have identified a novel signaling network regulated by blood flow in ECs-the chemokine receptor CXCR3 (CXC motif chemokine receptor 3) and one of its ligands, CXCL11 (CXC motif chemokine ligand 11)-that delimits EC angiogenic potential and promotes pericyte recruitment to ECs during development.

Methods

We investigated the role of CXCR3 on vascular development using both 2- and 3-dimensional in vitro assays, to study EC-pericyte interactions and EC behavioral responses to blood flow. Additionally, genetic mutants and pharmacological modulators were used in

SUBMITTER: Lee J 

PROVIDER: S-EPMC11594002 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature