Intergenic Interactions of ESR1, GSTO1 and AGER and Risk of Dementia in Community-Dwelling Elderly (SADEM Study).

ABSTRACT:

Background

Dementia causes the loss of functional independence, resulting in a decrease in the quality of life of those who suffer from it.

Aims

This study aimed to investigate the interactions influencing susceptibility to the development of dementia through multifactor dimensionality reduction (MDR).

Methods

the study population was made up of 221 cases and 534 controls. We performed an MDR analysis as well as a bioinformatic analysis to identify interactions between the genes GSTO1_rs4925, AGER_rs2070600, and ESR1_rs3844508 associated with susceptibility to dementia.

Results

We observed associations between the polymorphism of GSTO1 and risk of dementia for the site rs4925 with the recessive model (OR = 1.720, 95% CI = 1.166-2.537 p</

SUBMITTER: Juarez-Cedillo T 

PROVIDER: S-EPMC11594218 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature