The Evolving Role of Neoadjuvant Radiation Therapy in Pancreatic Adenocarcinoma.

ABSTRACT:

Background/objectives

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Surgical resection is the most reliable chance for cure, but high rates of positive margins and local failure persist. Neoadjuvant therapies (NAT), including chemotherapy and radiation therapy (RT), are being explored to improve surgical outcomes, particularly in borderline resectable (BRPC) and locally advanced pancreatic cancer (LAPC). This review aims to summarize the current landscape and future directions for neoadjuvant RT (NART) in PDAC.

Methods

The review includes a detailed analysis of past and ongoing clinical trials investigating various NART approaches in PDAC, with an emphasis on different RT techniques, fractionation schemes, and their integration into multimodal trea

SUBMITTER: Bryant JM 

PROVIDER: S-EPMC11594810 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature