RNAi-Mediated FoxO Silencing Inhibits Reproduction in Locusta migratoria.

ABSTRACT: FoxO is a downstream target gene of cellular nutrient and growth factors, oxidative stress responses, and insulin signaling pathways. It play a crucial role in insect growth, development, and reproduction. Locusta migratoria is a significant agricultural pest; therefore, the identification of novel control targets for its management is of significant importance. After injecting dsRNA to interfere with FoxO expression, we observed changes in the reproduction-related gene expression and ovary development through RT-qPCR and morphological observation. Simultaneously, the trehalose and glycogen contents were measured following RNAi. The results demonstrate that interference with FoxO significantly downregulates key genes in the Hippo pathway and Notch gene ex

SUBMITTER: Xu J 

PROVIDER: S-EPMC11594837 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature