Immunomodulation and Protective Effects of <i>Cordyceps militaris</i> Extract Against <i>Candida albicans</i> Infection in <i>Galleria mellonella</i> Larvae.

ABSTRACT: Cordyceps militaris-derived formulations are currently used for multiple purposes because of their medical properties, especially immune system modulation. This study analyzes the inhibitory effects of C. militaris aqueous extract on Candida albicans infections and the immune response in larvae of the greater wax moth Galleria mellonella (Lepidoptera: Pyralidae). Larvae exhibited melanization within 1 h of being infected with C. albicans inoculum at a concentration of 10⁶ cells/larvae, and died within 24 h from a lethal dose. Aqueous extract of C. militaris proved to be nontoxic at concentrations of 0.25 and 0.125 mg/larvae, and had the greatest ability to prolong the survival of larvae infected with a sublethal dose of C. albicans

SUBMITTER: Eiamthaworn K 

PROVIDER: S-EPMC11595007 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature