SOCS1 Inhibits IL-6-Induced CD155 Overexpression in Lung Adenocarcinoma.

ABSTRACT: CD155, also known as the poliovirus receptor (PVR), is a crucial molecule in the development and progression of cancer, as its overexpression favors immune evasion and resistance to immunotherapy. However, little is known about the mechanisms that regulate its overexpression. Proinflammatory factors produced by various cellular components of the tumor microenvironment (TME) have been associated with CD155 expression. We analyzed the effect of interleukin (IL)-6 on CD155 expression in lung adenocarcinoma. We found a positive relationship between mRNA and protein levels. This correlation was also observed in bioinformatics analysis and in biopsies and serum from patients with lung adenocarcinoma. Interestingly, lung adenocarcinoma cell lines expressing suppressor of cytokine signaling 1 (SOC

SUBMITTER: Marroquin-Mucino M 

PROVIDER: S-EPMC11595078 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature