Antibacterial and Antitumor Activities of Synthesized Sarumine Derivatives.

ABSTRACT: Our aim in this study was to explain the biological activity of the latest azafluoranthene. The natural product sarumine (12) and its derivatives (13-17) were synthesized and evaluated for their antibacterial and antitumor activities. The synthesis involved a simplified reaction pathway based on biaryl-sulfonamide-protected cyclization, and the compounds were characterized and studied using spectroscopic methods (¹HNMR and ¹³CNMR). Most of the compounds demonstrated improved antibacterial activity. Notably, sarumine demonstrated potent activity against S. aureus and B. subtilis, with an MIC of 8 μg/mL, showing comparable inhibitory effects to the positive control. Furthermore, molecular simulation studies indicated that sarumi

SUBMITTER: Yang F 

PROVIDER: S-EPMC11595285 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature