Structure and Fungicidal Activity of Secondary Metabolites Isolated from Trichoderma hamatum b-3.

ABSTRACT: Two new harziane diterpenes (1-2), five undescribed cyclonerane sesquiterpenes (3-7), and three known compounds, 11-cycloneren-3, 7, 10-triol (8), harziandione (9), and dehydroacetic acid (10), were isolated from Trichoderma hamatum b-3. Their structures were elucidated via comprehensive inspection of spectral evidence in HRESIMS and 1D and 2D NMR, and the absolute configuration of 1-8 was confirmed by NMR, ECD calculation, as well as Mosher's method. In vitro fungicidal activity showed that some compounds showed great inhibitory activity against pathogenic fungi, including Fusarium graminearum, Sclerotinia sclerotiorum, Botrytis cinerea, and Rhizoctonia solani, among which compound 10

SUBMITTER: Huang L 

PROVIDER: S-EPMC11595493 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature