New 24-Membered Macrolactines from an Arctic Bacterium Bacillus amyloliquefaciens SCSIO 41392 and Their Anti-Pathogenicity Evaluation.

ABSTRACT: Three new 24-membered macrolactines, amylomacrolactines A-C (1-3), along with two known compounds 4 and 5, were isolated from the Arctic bacteria Bacillus amyloliquefaciens SCSIO 41392. The configurations of 1-3 were assigned by a combination of coupling constants, NOESY, and analysis of MM2-optimized conformation, as well as by comparison with reports in the literature. Compounds 1 and 2 showed quorum sensing (QS) inhibitory activities against the Pseudomonas aeruginosa (P. aeruginosa) PQS system and suppressed PQS-regulated virulence factor pyocyanin synthesis. In addition, compounds 3-5 affected the production of another essential virulence factor, siderophore of pyoverdine (PVD), in P. aeruginosa

SUBMITTER: Song Y 

PROVIDER: S-EPMC11595553 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature