Antiprotozoal Natural Products from Endophytic Fungi Associated with Cacao and Coffee.

ABSTRACT:

Background

Collectively, leishmaniasis and Chagas disease cause approximately 8 million cases and more than 40,000 deaths annually, mostly in tropical and subtropical regions. The current drugs used to treat these diseases have limitations and many undesirable side effects; hence, new drugs with better clinical profiles are needed. Fungal endophytes associated with plants are known to produce a wide array of bioactive secondary metabolites, including antiprotozoal compounds. In this study, we analyzed endophytic fungal isolates associated with Theobroma cacao and Coffea arabica crop plants, which yielded extracts with antitrypanosomatid activity.

Methods

Crude extracts were subjected to bioassay-guided isolation by HPLC, followed by spectrometric and spectrosco

SUBMITTER: Boya P CA 

PROVIDER: S-EPMC11596112 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature