Signal Transducer and Activator of Transcription 4 (STAT4) Association with Pituitary Adenoma.

ABSTRACT: Background/Objectives: This study aims to investigate whether Signal Transducer and Activator of Transcription 4 (STAT4) influences the anti-tumor immune response and is possibly involved in the initiation or relapse of pituitary adenomas (PAs) by examining STAT4 polymorphisms and serum levels. This research seeks to uncover potential connections that could inform future therapeutic strategies and improve our understanding of PA pathogenesis. Materials and Methods: This study was conducted at the Laboratory of Ophthalmology, Lithuanian University of Health Sciences. DNA was extracted from peripheral venous blood samples, and the genotyping of four STAT4 SNPs (rs7574865, rs10181656, rs7601754, and rs10168266) was performed using real-time PCR with TaqMan^® Gen

SUBMITTER: Gedvilaite-Vaicechauskiene G 

PROVIDER: S-EPMC11596619 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature