Unveiling the truth: Pathogen infections linked to miscarriage: A STROBE-Compliant Mendelian randomization study.

ABSTRACT: Miscarriage represents a prevalent yet insufficiently studied adverse pregnancy outcome. The definitive causal links between various pathogens and miscarriage remain to be established. To investigate the causal connections between pathogen infections and miscarriage, we utilized a two-sample bidirectional Mendelian randomization (MR) analysis. We sourced genome-wide association studies data on pathogen infections from the UK Biobank, which included serological markers for infectious diseases and comprehensive whole-genome genetic information from approximately 10,000 individuals. Additionally, genome-wide association studies data on miscarriages were collected from 3 distinct European populations for our analysis. The MR analysis was primarily conducted using the inverse variance weighted

SUBMITTER: Zhou J 

PROVIDER: S-EPMC11596664 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature