An Overview of Lsr2 Repressor Effect in Streptomyces spp. Secondary Metabolism.

ABSTRACT: The genus Streptomyces is one of the largest producers of secondary metabolites with bioactive properties of interest. However, many of the genes involved in synthesizing these compounds are silenced under laboratory conditions. One of the strategies used to activate these metabolic pathways is the elimination of repressor genes, which prevent the transcription of other genes. In this work, the lsr2 gene has been selected for study since it is a repressor with a preference for binding to AT-rich regions, which makes it exert its effect especially on those horizontally transferred gene sequences that have a very different GC content to the core Streptomyces spp. genome. Therefore, the effects of the deletion of this gene are observed, and, in addition, a mapping of the

SUBMITTER: Cuervo L 

PROVIDER: S-EPMC11596768 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature