New Chalcone-Derived Molecule for the Topical Regulation of Hyperpigmentation and Skin Aging.

ABSTRACT: Background/Objectives: Skin hyperpigmentation is a biological process that results in an excessive production of melanin and is highly regulated by several mechanisms, tyrosinase being one of the key enzymes involved. Current reported inhibitors lack clinical efficacy, show toxic side effects, have poor bioavailability, or low formulation compatibility. The aim of this study was to design a new effective tyrosinase inhibitor for topical hyperpigmentation and anti-aging treatments. Methods: Homology modeling was used to build the tridimensional structure of human tyrosinase, and virtual docking was used to predict molecule-enzyme binding modes. The tyrosinase activity of the designed and synthesized compounds was assessed and water solubility was determined by HPLC. Cell assay

SUBMITTER: Martinez-Gutierrez A 

PROVIDER: S-EPMC11597169 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature