Heat Shock Factor HSFA6b Mediates Mitochondrial Unfolded Protein Response in Arabidopsis thaliana.

ABSTRACT: Mitochondria are important organelles in eukaryotes and are involved in various metabolic processes. Mitochondrial proteotoxic stress triggers the mitochondrial unfolded protein response (UPR^mt) to restore mitochondrial protein homeostasis and maintain normal life activities. However, the regulatory mechanism of plant UPR^mt remains to be revealed in Arabidopsis. Based on the fact that UPR^mt activates heat shock protein (HSP) genes, we identified the heat shock transcription factor HSFA6b as a key regulator mediating UPR^mt through reverse genetics. HSFA6b responded to mitochondrial proteotoxic stress and regulated mitochondrial heat shock proteins' genes' (mtHSPs) expression. HSFA6b translocated to the nuclear after tre

SUBMITTER: Yu G 

PROVIDER: S-EPMC11597222 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature