The Impact of a Ketogenic Diet on Late-Stage Pancreatic Carcinogenesis in Mice: Efficacy and Safety Studies.

ABSTRACT:

Background

High-fat diets (HFDs) have been associated with an increased risk of pancreatic cancer. In contrast, ketogenic diets (KDs) have been shown to display anti-tumor characteristics. The objective of this work was to evaluate the efficacy of a KD on late-stage pancreatic carcinogenesis in a genetically modified mouse model of pancreatic cancer [LSL-Kras^G12D/+; Ptf1-Cre (KC) mice], as well as its liver safety, and to compare it to that of an HFD.

Methods

Six-month-old female and male KC mice were randomly allocated to either a control diet (CD) (%kcal: 20% fat, 15% protein, 65% carbohydrates), an HFD (%kcal: 40% fat, 15% protein, 45% carbohydrate) or a KD (%kcal: 84% fat, 15% protein, 1% carbohydrate) and fed these diets for 6 months.

Results

SUBMITTER: Cortez NE 

PROVIDER: S-EPMC11597385 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature