Pomegranate Peel Extract Mitigates Diarrhea-Predominant Irritable Bowel Syndromes via MAPK and NF-κB Pathway Modulation in Rats.

ABSTRACT:

Background

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common chronic functional gastrointestinal disorder that causes diarrheal and intestinal barrier disruptions. Although pomegranate peel extract (PPE) has been reported for the treatment of diarrheal and intestinal inflammation, its effectiveness and mechanisms specifically for the treatment of IBS-D remain unknown.

Objectives

This study aimed to explore the therapeutic effect of PPE on IBS-D and elucidate its underlying mechanisms.

Methods

A high-fat diet, restraint stress, and senna gavage were combined to establish a rat model mimicking IBS-D, to evaluate the therapeutic effects of PPE. Network pharmacology analysis, serum medicinal chemistry, and transcriptomics were employed to investigate poten

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11597445 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature