Network Pharmacology and Molecular Docking Reveal Anti-Asthmatic Potential of Zephyranthes rosea Lindl. in an Ovalbumin-Induced Asthma Model.

ABSTRACT: Background: This study aimed to evaluate the anti-inflammatory effects of a Zephyranthes rosea in an ovalbumin-induced asthma model. Methods: Allergic asthma was induced in mice via intraperitoneal injection, followed by intranasal ovalbumin challenge. Methanolic extract of Z. rosea bulb was orally administered to asthmatic mice for 14 days. Hematological parameters for bronchoalveolar lavage fluid (BALF) and blood were analyzed. The mRNA expression levels of interleukins and transforming growth factor beta (TGF-β1) in lung tissues were determined using reverse transcriptase-polymerase chain reaction (RT-PCR). Network pharmacology analysis was used to find possible Z. rosea targets. After building a protein-protein interaction network to find hub g

SUBMITTER: Ali A 

PROVIDER: S-EPMC11597469 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature