Quantitative Approach to Explore Regulatory T Cell Activity in Immuno-Oncology.

ABSTRACT: The failure of immunotherapies in cancer patients is being widely studied due to the complexities present in the tumor microenvironment (TME), where regulatory T cells (Treg) appear to actively participate in providing an immune escape mechanism for tumors. Therefore, therapies to specifically inhibit tumor-infiltrating Treg represent a challenge, because Treg are distributed throughout the body and provide physiological immune homeostasis to prevent autoimmune diseases. Characterization of immunological and functional profiles could help to identify the mechanisms that need to be inhibited or activated to ensure Treg modulation in the tumor. To address this, quantitative in silico approaches based on mechanistic mathematical models integrating multi-scale information from immune and tumor

SUBMITTER: Serrano A 

PROVIDER: S-EPMC11597491 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature